2,2,2-Trifluoroethyl Methanesulfonate → 2-Methyl-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

HRID 8884Notes

Reaction equation

HRID 8884 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.S(O[CH2:21][C:22]([F:25])([F:24])[F:23])(=O)(=O)C>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([CH2:21][C:22]([F:25])([F:24])[F:23])[CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 5565652,2,2-Trifluoroethyl MethanesulfonateHCID 178418884HCID 178418884, compound

Product 1

HCID 112659352-Methyl-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

Procedure

The title compound, MS: m/e=280.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2,2,2-trifluoroethyl mesylate.

Sources & evidence

ORD record
ord-08a2d881db674a16b9f53b7e318f89a5
Source dataset
uspto-grants-2006_08
Patent number
US07091222B2

Reaction notes

Loading…