Trifluoroacetic acid → HCID 68500250, compound

HRID 888417Notes

Reaction equation

HRID 888417 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:12]=[C:11]([C:19]([O:21]C(C)(C)C)=[O:20])[CH:10]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([S:15]([CH3:18])(=[O:16])=[O:17])[CH:12]=[C:11]([C:19]([OH:21])=[O:20])[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68502632HCID 68502632, compound

Product 1

HCID 68500250HCID 68500250, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2′,4′-difluoro-5-(methylsulfonyl)biphenyl-3-carboxylate (77 mg, 0.21 mmol) in dichloromethane (1.05 mL) was added trifluoroacetic acid (1.05 mL). The mixture was stirred at ambient temperature for 30 min. The mixture was concentrated to dryness to give the title compound.

Workup

  1. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-815dde1b6b48479999f26cab808991f8
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

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