Lithium Hydroxide → [3-(2-Benzylsulfanylmethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid

HRID 888481Notes

Reaction equation

HRID 888481 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[CH2:22][S:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:7]=1)C.[OH-].[Li+]>CO.O>[CH2:24]([S:23][CH2:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[O:14][C:8]1[CH:7]=[C:6]([CH2:5][C:4]([OH:31])=[O:3])[CH:11]=[CH:10][C:9]=1[O:12][CH3:13])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58372812[3-(2-Benzylsulfanylmethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Product 1

HCID 44608140[3-(2-Benzylsulfanylmethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

[3-(2-Benzylsulfanylmethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester was hydrolyzed with lithium hydroxide in MeOH and H2O to give the title compound.

Sources & evidence

ORD record
ord-11604af8f913456886fb74f64d2e249d
Source dataset
uspto-grants-2012_08
Patent number
US08247602B2

Reaction notes

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