Ethanol → Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

HRID 888491Notes

Reaction equation

HRID 888491 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=1)[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1605623-Hydroxy-4-methoxybenzeneacetic acid

Product 1

HCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Procedure

To 3-hydroxy-4-methoxyphenylacetic acid (5.0 g, 23.8 mmol) in EtOH (100 mL) was added sulfuric acid (1 mL), and the reaction was stirred overnight at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated to give the desired product.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-a612162f54a946f6b691f8cf423f0ff0
Source dataset
uspto-grants-2012_08
Patent number
US08247602B2

Reaction notes

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