Hydrogen Bromide → HCID 58372746, compound

HRID 888519Notes

Reaction equation

HRID 888519 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]C)=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=2[CH2:24][S:25][CH2:26][C:27]([F:30])([F:29])[F:28])[CH:7]=1)C.Br>C(O)(=O)C>[OH:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][C:4]([OH:31])=[O:3])=[CH:7][C:8]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=1[CH2:24][S:25][CH2:26][C:27]([F:30])([F:28])[F:29]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 58372816HCID 58372816, compound

Product 1

HCID 58372746HCID 58372746, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

{4-Methoxy-3-[4-nitro-2-(2,2,2-trifluoro-ethylsulfanylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (1.5 g, 3.6 mmol) was treated with 48% hydrogen bromide in acetic acid (1:1; 20 mL) at 100° C. overnight. After work-up with EtOAc and H2O, the crude material was purified by preparative HPLC to give {4-hydroxy-3-[4-nitro-2-(2,2,2-trifluoro-ethylsulfanylmethyl)-phenoxy]-phenyl}-acetic acid.

Workup

  1. customAfter work-up with EtOAc and H2O, the crude material was purified by preparative HPLC

Sources & evidence

ORD record
ord-98f67bc8b3884edea6f9863cc13b80c1
Source dataset
uspto-grants-2012_08
Patent number
US08247602B2

Reaction notes

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