Hydrochloric Acid → HCID 58372824, compound

HRID 888520Notes

Reaction equation

HRID 888520 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=1[CH2:22][S:23][CH2:24][C:25]([F:28])([F:27])[F:26].Cl.[CH3:30]CO>>[CH3:30][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=2[CH2:22][S:23][CH2:24][C:25]([F:28])([F:26])[F:27])[CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 58372746HCID 58372746, compound

Product 1

HCID 58372824HCID 58372824, compound

Conditions

Temperature
80 °C

Procedure

{4-Hydroxy-3-[4-nitro-2-(2,2,2-trifluoro-ethylsulfanylmethyl)-phenoxy]-phenyl}-acetic acid (3.6 mmol) and hydrogen chloride (4N in 1,4-dioxane) were combined in EtOH and stirred at 80° C. for 3 hours. After concentrating to dryness, the residue was purified by silica gel chromatography to give {4-hydroxy-3-[4-nitro-2-(2,2,2-trifluoro-ethylsulfanylmethyl)-phenoxy]-phenyl}-acetic acid methyl ester.

Workup

  1. concentrationAfter concentrating to dryness
  2. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-da39c8b857544c0c88edcf0637a32a13
Source dataset
uspto-grants-2012_08
Patent number
US08247602B2

Reaction notes

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