Ammonia → 3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionamide

HRID 888572Notes

Reaction equation

HRID 888572 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.C(N1C=CN=C1)([N:22]1C=CN=C1)=O.N>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:9][C:10]([NH2:22])=[O:11])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 682631,1'-CarbonyldiimidazoleHCID 576913963-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionic acid

Product 1

HCID 576913943-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionamideYield 36%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionic acid* (0.25 g, 0.74 mmol) and 1,1′-carbonyldiimidazole (0.24 g, 1.47 mmol) in dichloromethane was stirred for 45 minutes before the addition of ammonia (2M solution in methanol, 3.68 ml, 7.36 mmol). The reaction mixture was stirred for 2 hours, solvent removed under reduced pressure and residue was purified over flash silica chromatography eluting with ethyl acetate/petroleum ether (1:4) to afford the title compound (0.091 g, 36% yield). LC/MS: (PS-A2) Rt 3.08 [M+H]+ 339.93.

Workup

  1. customsolvent removed under reduced pressure and residue
  2. customwas purified over flash silica chromatography
  3. washeluting with ethyl acetate/petroleum ether (1:4)

Sources & evidence

ORD record
ord-9bb2fd86d9444774a883d357e6757afc
Source dataset
uspto-grants-2012_08
Patent number
US08247576B2

Reaction notes

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