Pyrazole → HCID 11324521, compound

HRID 888633Notes

Reaction equation

HRID 888633 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)([F:11])[CH2:9][NH2:10])=[CH:4][CH:3]=1.[NH:19]1[CH:23]=[CH:22][CH:21]=[N:20]1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:8]([F:11])([C:5]2[CH:6]=[CH:7][C:2]([C:22]3[CH:23]=[N:19][NH:20][CH:21]=3)=[CH:3][CH:4]=2)[CH2:9][NH2:10])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 59331946HCID 59331946, compound

Product 1

HCID 11324521HCID 11324521, compound

Procedure

2,2-Bis-(4-chloro-phenyl)-2-fluoro-ethylamine was reacted with 4,4,4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 except that heating was carried out at 100° C. for 5 minutes using 300 W power in a CEM microwave, to obtain the title compound. LCMS (PS-B4) Rt 6.69 min [M−F−]+296. 1H NMR (Me-d3-OD) δ 4.04 (2H, d), 7.47-7.55 (6H, m), 7.77 (2H, d), 8.41 (2H, d).

Sources & evidence

ORD record
ord-539ba82d138a405db334cad604e0cd68
Source dataset
uspto-grants-2012_08
Patent number
US08247576B2

Reaction notes

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