3-Bromo-1,1,1-trifluoropropane → HCID 54299918, compound

HRID 888636Notes

Reaction equation

HRID 888636 reaction equation
[C:1]([O-:4])(=[S:3])[CH3:2].[K+].Br[CH2:7][CH2:8][C:9]([F:12])([F:11])[F:10]>CN1CCCC1=O>[C:1]([O:4][CH2:7][CH2:8][C:9]([F:12])([F:11])[F:10])(=[S:3])[CH3:2]

Participants

4

Reactant 2

HCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 23670855Potassium ethanethioate

Product 1

HCID 54299918HCID 54299918, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a suspension of 7.35 g of potassium thioacetate in 30 ml of N-methyl-2-pyrrolidone was added dropwise 11.39 g of 3-bromo-1,1,1-trifluoropropane over 15 minutes at 0° C. under a nitrogen atmosphere, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was heated to 80° C., followed by distillation under reduced pressure to obtain 9.99 g of 3,3,3-trifluoropropyl thioacetate represented by the formula:

Workup

  1. temperatureThe reaction mixture was heated to 80° C.
  2. distillationfollowed by distillation under reduced pressure

Sources & evidence

ORD record
ord-d1b22a996a2b45e8ba0fec29aaaf56b1
Source dataset
uspto-grants-2012_08
Patent number
US08247596B2

Reaction notes

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