HRID888657

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2781139

7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline

C10H10F3N

结构：COC(=O)C(CC(C)C)c1cc(OS(=O)(=O)C(F)(F)F)cc(-c2ccc(C(F)(F)F)cc2)c1

HCID59004769

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(CC(C)C)c1cc(-c2ccc(C(F)(F)F)cc2)cc(N2CCCc3ccc(C(F)(F)F)cc32)c1

HCID57666622

未命名化合物

收率 8%

PROCEDURE

实验过程

The title compound was prepared in 8% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and 7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline under the conditions described in Example 24, step (a).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cca5ea5c400642a1866000790a65baa4
来源数据集: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08247610B2
来源说明: uspto-grants-2012_08

反应 SMILES

[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:34][C:35]([F:47])([F:46])[C:36]1[CH:45]=[C:44]2[C:39]([CH2:40][CH2:41][CH2:42][NH:43]2)=[CH:38][CH:37]=1>>[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:27][CH:28]=2)[CH:12]=[C:13]([N:43]2[C:44]3[C:39](=[CH:38][CH:37]=[C:36]([C:35]([F:34])([F:46])[F:47])[CH:45]=3)[CH2:40][CH2:41][CH2:42]2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]