7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline → 4-Methyl-2-[4'-trifluoromethyl-5-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-yl)-biphenyl-3-yl]-pentanoic acid methyl ester

HRID 888657Notes

Reaction equation

HRID 888657 reaction equation
[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:34][C:35]([F:47])([F:46])[C:36]1[CH:45]=[C:44]2[C:39]([CH2:40][CH2:41][CH2:42][NH:43]2)=[CH:38][CH:37]=1>>[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:27][CH:28]=2)[CH:12]=[C:13]([N:43]2[C:44]3[C:39](=[CH:38][CH:37]=[C:36]([C:35]([F:34])([F:46])[F:47])[CH:45]=3)[CH2:40][CH2:41][CH2:42]2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 27811397-(Trifluoromethyl)-1,2,3,4-tetrahydroquinolineHCID 59004769HCID 59004769, compound

Product 1

HCID 576666224-Methyl-2-[4'-trifluoromethyl-5-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-yl)-biphenyl-3-yl]-pentanoic acid methyl esterYield 8%

Procedure

The title compound was prepared in 8% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and 7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline under the conditions described in Example 24, step (a).

Sources & evidence

ORD record
ord-cca5ea5c400642a1866000790a65baa4
Source dataset
uspto-grants-2012_08
Patent number
US08247610B2

Reaction notes

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