HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline → 4-Methyl-2-[4'-trifluoromethyl-5-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-yl)-biphenyl-3-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline | HCID 2781139 | — |
| Reactant | HCID 59004769 | HCID 59004769 | — |
| Product | 4-Methyl-2-[4'-trifluoromethyl-5-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-yl)-biphenyl-3-yl]-pentanoic acid methyl ester | HCID 57666622 | 8% |
Reaction Steps
The title compound was prepared in 8% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and 7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline under the conditions described in Example 24, step (a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247610B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-cca5ea5c400642a1866000790a65baa4 |
| Source note | uspto-grants-2012_08 |