1-Hydroxybenzotriazole → HCID 17796731, compound

HRID 888662Notes

Reaction equation

HRID 888662 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].Cl.[CH3:14][NH:15][O:16][CH3:17].C1C=CC2N(O)N=NC=2C=1>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([N:15]([O:16][CH3:17])[CH3:14])=[O:6]

Participants

5

Reactant 3

HCID 757711-HydroxybenzotriazoleHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 8531543,4,5-Trifluorobenzoic acid

Product 1

HCID 17796731HCID 17796731, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example 29, step (b), reaction of 3,4,5-trifluoro-benzoic acid with N,O-dimethylhydroxylamine HCl in present of HOBT, EDA, TEA in DCM followed the column purification gave the title compound; Calcd MW 219.16. Found MH+ 220.1.

Workup

  1. customthe column purification

Sources & evidence

ORD record
ord-11793d4295e6458eafce0552834019dc
Source dataset
uspto-grants-2012_08
Patent number
US08247610B2

Reaction notes

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