1,2,3,4-Tetrahydroisoquinoline → 4-Methyl-2-[-5-(3,4-dihydroisoquinolin-2(1H)-yl)-4'-(trifluoromethyl)biphenyl-3-yl]-pentanoic acid methyl ester

HRID 888668Notes

Reaction equation

HRID 888668 reaction equation
[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[CH2:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][CH2:36][NH:35]1>>[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:32])[F:31])=[CH:25][CH:24]=2)[CH:12]=[C:13]([N:35]2[CH2:36][CH2:37][C:38]3[C:43](=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH2:34]2)[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 59004769HCID 59004769, compound

Product 1

HCID 576666374-Methyl-2-[-5-(3,4-dihydroisoquinolin-2(1H)-yl)-4'-(trifluoromethyl)biphenyl-3-yl]-pentanoic acid methyl esterYield 85%

Procedure

The title compound was prepared in 85% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and tetrahydroisoquinoline under the conditions described in Example 24, step (a).

Sources & evidence

ORD record
ord-9cfe94b2320e4c698f14a8545bd571ec
Source dataset
uspto-grants-2012_08
Patent number
US08247610B2

Reaction notes

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