HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroisoquinoline → 4-Methyl-2-[-5-(3,4-dihydroisoquinolin-2(1H)-yl)-4'-(trifluoromethyl)biphenyl-3-yl]-pentanoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Reactant | HCID 59004769 | HCID 59004769 | — |
| Product | 4-Methyl-2-[-5-(3,4-dihydroisoquinolin-2(1H)-yl)-4'-(trifluoromethyl)biphenyl-3-yl]-pentanoic acid methyl ester | HCID 57666637 | 85% |
Reaction Steps
The title compound was prepared in 85% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester and tetrahydroisoquinoline under the conditions described in Example 24, step (a).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247610B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-9cfe94b2320e4c698f14a8545bd571ec |
| Source note | uspto-grants-2012_08 |