Iodine → 1-[2-(4-Bromophenyl)-2-oxoethyl]pyridin-1-ium iodide
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[I:11]I.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[I-:11].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH2:9][N+:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
10.0 g of 4′-bromoacetophenone, 12.8 g of iodine, and 80 ml of pyridine were added and the whole was heated and stirred at 100° C. for 3 hours. After cooling to room temperature, 100 ml of water was added and purification by recrystallization was performed. Drying was performed under reduced pressure at 70° C. for 12 hours to obtain 15.5 g (yield 76%) of 4-bromophenacylpyridinium iodide as a brown powder.
Workup
- temperaturethe whole was heated
- temperatureAfter cooling to room temperature
- custompurification
- customby recrystallization
- customDrying
- waitwas performed under reduced pressure at 70° C. for 12 hours
Sources & evidence
- ORD record
- ord-c5b8a63754e445628be1ebc4599c535d
- Source dataset
- uspto-grants-2012_08
- Patent number
- US08252431B2
Reaction notes
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