Sodium borohydride → 2-(2-methyl-phenyl)-N-methyl-2-hydroxy-acetamide

HRID 888712Notes

Reaction equation

HRID 888712 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[C:9]([NH:11][CH3:12])=[O:10].[BH4-].[Na+]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([OH:13])[C:9]([NH:11][CH3:12])=[O:10]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 15239356N-methyl-2-(2-methylphenyl)-2-oxoacetamide

Product 1

HCID 669364422-(2-methyl-phenyl)-N-methyl-2-hydroxy-acetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Racemic 2-(2-methyl-phenyl)-N-methyl-2-hydroxy-acetamide was synthesized by reducing 2-(2-methyl-phenyl)-N-methyl-2-oxo-acetamide with NaBH4 in methanol.

Sources & evidence

ORD record
ord-003b3cf8705c4510a16aa3f43ef3d674
Source dataset
uspto-grants-2012_08
Patent number
US08252563B2

Reaction notes

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