HCID 10657319, compound → HCID 86626934, compound

HRID 888725Notes

Reaction equation

HRID 888725 reaction equation
[NH:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[NH2:2].[C:10]([CH:18]([C:24](=O)[CH3:25])[CH2:19][C:20]([O:22][CH3:23])=[O:21])(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[CH3:25][C:24]1[C:18]([CH2:19][C:20]([O:22][CH3:23])=[O:21])=[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][C:8]=2[CH3:9])[N:2]=1

Participants

4

Reactant 2

HCID 10657319HCID 10657319, compoundHCID 121517063-Hydrazinyl-4-methylpyridine

Product 1

HCID 86626934HCID 86626934, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.315 g (2.049 mmol) of 3-hydrazino-4-methylpyridine in 5.00 ml of ethanol was added to 0.400 g (1.708 mmol) of methyl 3-benzoyl-4-oxopentanoate, and the mixture was stirred under reflux for 8 h. The solvent was removed under reduced pressure giving, after chromatography of the residue, 0.305 g (47% of theory) of a reddish wax-like solid. 1H-NMR (CDCl3): see Table 2.

Workup

  1. temperatureunder reflux for 8 h
  2. customThe solvent was removed under reduced pressure
  3. customgiving

Sources & evidence

ORD record
ord-1e0377ac66c14a0284680164a1f78829
Source dataset
uspto-grants-2012_08
Patent number
US08252723B2

Reaction notes

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