3-(Dimethylamino)piperidine → [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-dimethyl-amine

HRID 888918Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17]CN(C(C)(C)C(N(C)C)=O)C[CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH3:32][N:33]([CH3:40])[CH:34]1[CH2:39][CH2:38]CNC1>>[Cl:1][C:2]1[N:3]=[C:4]([N:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:13][CH2:38][CH2:39][CH:34]([N:33]([CH3:40])[CH3:32])[CH2:17]3)=[CH:8][C:6]=2[N:7]=1

Participants

Reactant 2

HCID 144598543-(Dimethylamino)piperidine

HCID 591512572-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide

Product 1

HCID 59151317[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-dimethyl-amine

Procedure

Prepared using the method used in the preparation of 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide using dimethyl-piperidin-3-yl-amine in place of N,N-dimethyl-2-piperazin-1-yl-isobutyramide. The title compound was obtained as an off-white solid (180 mg, 76%).

Workup

customPrepared

Sources & evidence

ORD record: ord-ccfd70f14ecf4b6bb1f35f562e518daa
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08252792B2

Reaction notes

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