3-(Dimethylamino)piperidine → [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-dimethyl-amine

Participants

Role	Name	HCID	Charge
Reactant	3-(Dimethylamino)piperidine	HCID 14459854	—
Reactant	2-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide	HCID 59151257	—
Product	[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-3-yl]-dimethyl-amine	HCID 59151317	—

Reaction Steps

Prepared using the method used in the preparation of 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide using dimethyl-piperidin-3-yl-amine in place of N,N-dimethyl-2-piperazin-1-yl-isobutyramide. The title compound was obtained as an off-white solid (180 mg, 76%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08252792B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-ccfd70f14ecf4b6bb1f35f562e518daa
Source note	uspto-grants-2012_08