(2S)-2-Isopropylpiperazine, N1-BOC protected → (S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester

HRID 888919Notes

Reaction equation

HRID 888919 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11]N3CCN(C(C)(C)C(N(C)C)=O)CC3)=[CH:8][C:6]=2[N:7]=1.[C:32]([O:36][C:37]([N:39]1[CH2:44][CH2:43][NH:42][CH2:41][C@@H:40]1[CH:45]([CH3:47])[CH3:46])=[O:38])([CH3:35])([CH3:34])[CH3:33]>>[C:32]([O:36][C:37]([N:39]1[CH2:44][CH2:43][N:42]([CH2:11][C:9]2[S:10][C:5]3[C:4]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[N:3][C:2]([Cl:1])=[N:7][C:6]=3[CH:8]=2)[CH2:41][C@@H:40]1[CH:45]([CH3:47])[CH3:46])=[O:38])([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 17750439(2S)-2-Isopropylpiperazine, N1-BOC protectedHCID 591512572-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide

Product 1

HCID 59151324(S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester

Procedure

Prepared using the method used in the preparation of 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide using (S)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester in place of N,N-dimethyl-2-piperazin-1-yl-isobutyramide. The title compound was obtained as an off-white solid (182 mg, 80%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3615e5eb4c21452c885d176b07ce2bbb
Source dataset
uspto-grants-2012_08
Patent number
US08252792B2

Reaction notes

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