(2S)-2-Isopropylpiperazine, N1-BOC protected → (S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2-Isopropylpiperazine, N1-BOC protected	HCID 17750439	—
Reactant	2-[4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide	HCID 59151257	—
Product	(S)-4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester	HCID 59151324	—

Reaction Steps

Prepared using the method used in the preparation of 2-[4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazin-1-yl]-N,N-dimethyl-isobutyramide using (S)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester in place of N,N-dimethyl-2-piperazin-1-yl-isobutyramide. The title compound was obtained as an off-white solid (182 mg, 80%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08252792B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-3615e5eb4c21452c885d176b07ce2bbb
Source note	uspto-grants-2012_08