Hydrochloric Acid → HCID 68715431, compound

HRID 888927Notes

Reaction equation

HRID 888927 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([CH3:18])([CH3:17])[CH2:15][OH:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19]>ClCCl>[ClH:19].[CH3:18][C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)([CH3:17])[CH2:15][OH:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 574203451,1-Dimethylethyl 4-(2-hydroxy-1,1-dimethylethyl)-1-piperazinecarboxylate

Product 1

HCID 68715431HCID 68715431, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2-hydroxy-1,1-dimethyl-ethyl)-piperazin-1-carboxylic acid tert-butyl ester (0.42 g) in anhydrous dichloromethane (10 mL) was added 2M hydrogen chloride (8.4 ml) and the mixture stirred for 12 hours. The solvent was evaporated to give 2-methyl-2-piperazin-1-yl-propan-1-ol hydrochloride salt as a white solid.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-404f1e323d3c4cdc93c81190c7f8947a
Source dataset
uspto-grants-2012_08
Patent number
US08252792B2

Reaction notes

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