HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate | HCID 21082715 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1) | HCID 22281452 | — |
Reaction Steps
Add 4N HCl in 1,4-dioxane (86.096 mmoles, 21.524 mL) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (8.610 mmoles, 2.000 g) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate under reduced pressure to afford the title compound (8.679 mmoles, 1.780 g). MS (m/z): 133 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252798B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5543a4f165984544ae9b5d9454787701 |
| Source note | uspto-grants-2012_08 |