Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1)

HRID 888968Notes

Reaction equation

HRID 888968 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

Product 1

HCID 222814521-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add 4N HCl in 1,4-dioxane (86.096 mmoles, 21.524 mL) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (8.610 mmoles, 2.000 g) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate under reduced pressure to afford the title compound (8.679 mmoles, 1.780 g). MS (m/z): 133 (M+1).

Workup

  1. concentrationConcentrate under reduced pressure

Sources & evidence

ORD record
ord-5543a4f165984544ae9b5d9454787701
Source dataset
uspto-grants-2012_08
Patent number
US08252798B2

Reaction notes

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