1-Methylpiperazine → HCID 67426839, compound

HRID 888976Notes

Reaction equation

HRID 888976 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Cl:24])[N:6]2[CH2:11][CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[ClH:1].[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:5]1[N:6]([CH2:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:7]2[C:3]([N:4]=1)=[C:2]([N:29]1[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]1)[N:10]=[CH:9][N:8]=2

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 86642730HCID 86642730, compound

Product 1

HCID 67426839HCID 67426839, compound

Procedure

Displace 6-Chloro-8-(2-chloro-phenyl)-9-(tetrahydro-pyran-4-ylmethyl)-9H-purine with N-methylpiperazine and prepare hydrochloride salt using the same procedure as example 1 to give the title compound. MS (m/z): 427 (M+1)

Sources & evidence

ORD record
ord-8194920d06604c9dbc030d047a430c42
Source dataset
uspto-grants-2012_08
Patent number
US08252798B2

Reaction notes

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