Hydrochloric Acid → HCID 67425523, compound

Participants

Reaction Steps

Stir 8-(2-Chloro-phenyl)-6-(4-ethyl-piperazin-1-yl)-2-methyl-9-(tetrahydro-pyran-4-ylmethyl)-9H-purine (5.23 g, 11.5 mmol) in diethyl ether (45 mL) and add hydrogen chloride (4N in 1,4-dioxane, 2.9 mL, 11.5 mmol) at room temperature. After 2 hours collect the solid obtained by filtration and wash with diethyl ether. Vacuum dry to afford the title compound (5.4 g) MS (m/z): 455/457 (M+1−HCl).

Provenance & Evidence