Hydrochloric Acid → HCID 67425523, compound

HRID 888977Notes

Reaction equation

HRID 888977 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH2:26][CH:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[C:10]2[C:15]([N:16]=1)=[C:14]([N:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH3:24])[CH2:19][CH2:18]1)[N:13]=[C:12]([CH3:25])[N:11]=2.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH2:26][CH:27]2[CH2:28][CH2:29][O:30][CH2:31][CH2:32]2)[C:10]2[C:15]([N:16]=1)=[C:14]([N:17]1[CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH2:22]1)[N:13]=[C:12]([CH3:25])[N:11]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46833779HCID 46833779, compound

Product 1

HCID 67425523HCID 67425523, compoundYield 191.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Stir 8-(2-Chloro-phenyl)-6-(4-ethyl-piperazin-1-yl)-2-methyl-9-(tetrahydro-pyran-4-ylmethyl)-9H-purine (5.23 g, 11.5 mmol) in diethyl ether (45 mL) and add hydrogen chloride (4N in 1,4-dioxane, 2.9 mL, 11.5 mmol) at room temperature. After 2 hours collect the solid obtained by filtration and wash with diethyl ether. Vacuum dry to afford the title compound (5.4 g) MS (m/z): 455/457 (M+1−HCl).

Workup

  1. customAfter 2 hours collect the solid
  2. customobtained by filtration
  3. washwash with diethyl ether
  4. customVacuum dry

Sources & evidence

ORD record
ord-1505078293e84002a184ca16004b4aa8
Source dataset
uspto-grants-2012_08
Patent number
US08252798B2

Reaction notes

Loading…