HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888998Generated: October 31, 2026
2-Methyl-2-butanol → 2-[(5-tert-butyl-2-methylphenyl)amino]-6-[4-(1H-imidazol-1-yl)piperidin-1-yl]-N,N-dimethylisonicotinamide
https://huagongshe.com/reaction/888998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methyl-2-butanol | HCID 6405 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | 5-tert-Butyl-2-methylaniline | HCID 13089979 | — |
| Reactant | 2-chloro-6-[4-(1H-imidazol-1-yl)piperidin-1-yl]-N,N-dimethylisonicotinamide | HCID 86639110 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | 2-[(5-tert-butyl-2-methylphenyl)amino]-6-[4-(1H-imidazol-1-yl)piperidin-1-yl]-N,N-dimethylisonicotinamide | HCID 59191959 | — |
Reaction Steps
2-chloro-6-[4-(1H-imidazol-1-yl)piperidin-1-yl]-N,N-dimethylisonicotinamide (250 mg, 0.749 mmol), 5-tert-butyl-2-methylaniline (132 mg, 0.809 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl (187 mg, 0.392 mmol), Pd2(dba)3 (70 mg, 0.076 mmol) and potassium carbonate (119 mg, 0.861 mmol) were combined in a vial, sealed, and put under an atmosphere of N2. Degassed t-amyl alcohol (3 ml) was added. The mixture was stirred at 100° C. overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08252803B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-e8625ad4e2194824b8f0841ee706d526 |
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| Source note | uspto-grants-2012_08 |
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