反应详情

温度

100 °C

2-chloro-6-[4-(1H-imidazol-1-yl)piperidin-1-yl]-N,N-dimethylisonicotinamide (250 mg, 0.749 mmol), 5-tert-butyl-2-methylaniline (132 mg, 0.809 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl (187 mg, 0.392 mmol), Pd2(dba)3 (70 mg, 0.076 mmol) and potassium carbonate (119 mg, 0.861 mmol) were combined in a vial, sealed, and put under an atmosphere of N2. Degassed t-amyl alcohol (3 ml) was added. The mixture was stirred at 100° C. overnight.

1. customsealed