Hydrochloric Acid → HCID 44236501, compound

HRID 889004Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][N:11]2[CH:15]=[C:14]([C:16]3[N:24](COCC[Si](C)(C)C)[C:23]4[C:22](=[O:33])[N:21]([CH3:34])[C:20](=[O:35])[N:19]([CH3:36])[C:18]=4[N:17]=3)[CH:13]=[N:12]2)[CH:5]=[CH:6][CH:7]=1.Cl>CCO>[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][N:11]2[CH:15]=[C:14]([C:16]3[NH:24][C:23]4[C:22](=[O:33])[N:21]([CH3:34])[C:20](=[O:35])[N:19]([CH3:36])[C:18]=4[N:17]=3)[CH:13]=[N:12]2)[CH:5]=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 80 °C

Procedure

8-{1-[3-(3-Fluoro-phenyl)-prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dimethyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.100 g, 0.19 mmol) in EtOH (5 mL) was treated with 2N HCl (1.1 mL) and heated at 80° C. for 2 hrs. The reaction mixture was concentrated in vacuo, and the residue was triturated with diethyl ether to afford 8-{1-[3-(3-Fluoro-phenyl)-prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione in (0.040 mg, 54%) as a white solid.

Workup

concentrationThe reaction mixture was concentrated in vacuo
customthe residue was triturated with diethyl ether

Sources & evidence

ORD record: ord-1c15c138046c4ea9814fdf611b9cc0d6
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08252797B2

Reaction notes

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