Hydrochloric Acid → HCID 57429658, compound

HRID 889011Notes

Reaction equation

[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10](COCC[Si](C)(C)C)[C:9]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]#[C:31][C:32]4[CH:37]=[CH:36][C:35]([O:38][C:39]([F:42])([F:41])[F:40])=[CH:34][CH:33]=4)=[CH:24][CH:23]=3)=[N:8][C:7]=2[N:6]([CH2:43][CH2:44][CH3:45])[C:5]1=[O:46])[CH2:2][CH3:3].Cl>C(O)C>[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[NH:10][C:9]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]#[C:31][C:32]4[CH:33]=[CH:34][C:35]([O:38][C:39]([F:42])([F:41])[F:40])=[CH:36][CH:37]=4)=[CH:24][CH:23]=3)=[N:8][C:7]=2[N:6]([CH2:43][CH2:44][CH3:45])[C:5]1=[O:46])[CH2:2][CH3:3]

Participants

Conditions

Temperature: 85 °C

Procedure

A mixture of 1,3-dipropyl-8-{4-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyloxy]-phenyl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.053 g, 0.055 mmol), 2N HCl (2 ml), ethanol (2 ml) was heated at 85° C. for 2 hours. The mixture was cooled and the solvent was evaporated. The residue was washed with n-pentane to obtain 1,3-dipropyl-8-{4-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyloxy]-phenyl}-3,7-dihydro-purine-2,6-dione (0.038 g, 88%).

Workup

temperatureThe mixture was cooled
customthe solvent was evaporated
washThe residue was washed with n-pentane

Sources & evidence

ORD record: ord-ac3004daf024460482c97753351756d4
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08252797B2

Reaction notes

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