Hydrochloric Acid → HCID 57429614, compound

HRID 889015Notes

Reaction equation

HRID 889015 reaction equation
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10](COCC[Si](C)(C)C)[C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]#[C:29][C:30]4[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=4)[CH:26]=3)=[N:8][C:7]=2[N:6](COCC[Si](C)(C)C)[C:5]1=[O:45])[CH2:2][CH3:3].Cl>C(O)C>[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[NH:10][C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]#[C:29][C:30]4[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=4)[CH:26]=3)=[N:8][C:7]=2[NH:6][C:5]1=[O:45])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57988784HCID 57988784, compound

Product 1

HCID 57429614HCID 57429614, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 1-propyl-8-[1-(3-p-tolyl-prop-2-ynyl)-1H-pyrazol-4-yl]-3,7-bis-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione obtained in step 1 (0.035 g, 0.053 mmol;), 2 N HCl (1.5 ml), ethanol (3 ml) were heated at 85° C. for 6 hours. The mixture was cooled to 10-15° C. The solid obtained was filtered and washed with water (1 ml), ethanol (1 ml) to afford 1-propyl-8-[1-(3-p-tolyl-prop-2-ynyl)-1H-pyrazol-4-yl]-3,7-dihydro-purine-2,6-dione (0.009 g, 47%) as a brown solid.

Workup

  1. temperatureThe mixture was cooled to 10-15° C
  2. customThe solid obtained
  3. filtrationwas filtered
  4. washwashed with water (1 ml), ethanol (1 ml)

Sources & evidence

ORD record
ord-57f3feafc06840f39b98f5e3b742420e
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

Loading…