反应详情

温度

85 °C

A mixture of 8-{1-[1-(4-Isopropyl-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione obtained in step 5 (0.1 g, 0.23 mmol), 2 N HCl (3 ml), ethanol (2 ml) were heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. The solid obtained was filtered and washed with water (1 ml), diethyl ether (1 ml) to obtain 8-{1-[1-(4-isopropyl-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (0.071 g, 76%) as a white solid.

1. temperatureThe mixture was cooled to 10-15° C
2. customThe solid obtained
3. filtrationwas filtered
4. washwashed with water (1 ml), diethyl ether (1 ml)