Hydrochloric Acid → HCID 57988759, compound

HRID 889030Notes

Reaction equation

HRID 889030 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14](=[O:15])[CH2:13][CH:12]([CH2:16][N:17]3[CH:21]=[C:20]([C:22]4[N:30](COCC[Si](C)(C)C)[C:29]5[C:28](=[O:39])[N:27]([CH2:40][CH2:41][CH3:42])[C:26](=[O:43])[N:25]([CH2:44][CH2:45][CH3:46])[C:24]=5[N:23]=4)[CH:19]=[N:18]3)[CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Cl>C(O)C>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14](=[O:15])[CH2:13][CH:12]([CH2:16][N:17]3[CH:21]=[C:20]([C:22]4[NH:30][C:29]5[C:28](=[O:39])[N:27]([CH2:40][CH2:41][CH3:42])[C:26](=[O:43])[N:25]([CH2:44][CH2:45][CH3:46])[C:24]=5[N:23]=4)[CH:19]=[N:18]3)[CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57988783HCID 57988783, compound

Product 1

HCID 57988759HCID 57988759, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 8-{1-[1-(4-Isopropyl-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione obtained in step 5 (0.1 g, 0.23 mmol), 2 N HCl (3 ml), ethanol (2 ml) were heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. The solid obtained was filtered and washed with water (1 ml), diethyl ether (1 ml) to obtain 8-{1-[1-(4-isopropyl-phenyl)-5-oxo-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (0.071 g, 76%) as a white solid.

Workup

  1. temperatureThe mixture was cooled to 10-15° C
  2. customThe solid obtained
  3. filtrationwas filtered
  4. washwashed with water (1 ml), diethyl ether (1 ml)

Sources & evidence

ORD record
ord-618e5164c7dc49f1925bf53be98f6066
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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