Hydrochloric Acid → HCID 57429661, compound

HRID 889036Notes

Reaction equation

HRID 889036 reaction equation
[O:1]=[C:2]1[CH:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[N:21](COCC[Si](C)(C)C)[C:20]4[C:19](=[O:30])[N:18]([CH2:31][CH2:32][CH3:33])[C:17](=[O:34])[N:16]([CH2:35][CH2:36][CH3:37])[C:15]=4[N:14]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][N:3]1[C:38]1[CH:43]=[CH:42][CH:41]=[C:40]([C:44]([F:47])([F:46])[F:45])[CH:39]=1.Cl>C(O)C>[O:1]=[C:2]1[CH:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[NH:21][C:20]4[C:19](=[O:30])[N:18]([CH2:31][CH2:32][CH3:33])[C:17](=[O:34])[N:16]([CH2:35][CH2:36][CH3:37])[C:15]=4[N:14]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][N:3]1[C:38]1[CH:43]=[CH:42][CH:41]=[C:40]([C:44]([F:47])([F:46])[F:45])[CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57988799HCID 57988799, compound

Product 1

HCID 57429661HCID 57429661, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 8-{1-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione obtained in step 5 (0.1 g, 0.148 mmol), 2 N HCl (3 ml), ethanol (2 ml) was heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. The solid obtained was filtered and washed with water, diethyl ether to obtain the title compound as a white solid (0.067 g, 83%).

Workup

  1. temperatureThe mixture was cooled to 10-15° C
  2. customThe solid obtained
  3. filtrationwas filtered
  4. washwashed with water, diethyl ether

Sources & evidence

ORD record
ord-aea4d143f6924742bb1156e168b1bbc6
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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