反应详情

To a solution of 4-{4-[2,6-Dioxo-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxymethyl}-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (100 mg) in methanol (3 ml), methanolic HCl (3 N, 0.5 ml) was added at 0° C., reaction mixture was stirred at room temperature for 2 hrs. The reaction mixture was evaporated and the residue obtained was purified by column chromatography to offer 4-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester as a yellow solid (50 mg, 74%).

1. customreaction mixture
2. customThe reaction mixture was evaporated
3. customthe residue obtained
4. customwas purified by column chromatography