Phosphorus oxide (P4O10) → HCID 57988791, compound

HRID 889065Notes

Reaction equation

HRID 889065 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][N:10]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:20])[C:6](=[O:21])[N:5]([CH2:22][CH2:23][CH3:24])[C:4](=[O:25])[C:3]=1[NH:26][C:27]([C:29]1[CH:30]=[N:31][N:32]([CH2:34][CH:35]2[CH2:39][C:38](=[O:40])[N:37]([C:41]3[CH:46]=[CH:45][CH:44]=[C:43]([C:47]([F:50])([F:49])[F:48])[CH:42]=3)[CH2:36]2)[CH:33]=1)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>CN(C=O)C.O>[O:20]=[C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:18](=[O:19])[N:10]1[CH2:9][CH2:8][N:7]1[C:2]2[N:1]=[C:27]([C:29]3[CH:30]=[N:31][N:32]([CH2:34][CH:35]4[CH2:39][C:38](=[O:40])[N:37]([C:41]5[CH:46]=[CH:45][CH:44]=[C:43]([C:47]([F:50])([F:48])[F:49])[CH:42]=5)[CH2:36]4)[CH:33]=3)[NH:26][C:3]=2[C:4](=[O:25])[N:5]([CH2:22][CH2:23][CH3:24])[C:6]1=[O:21]

Participants

5

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 57988790HCID 57988790, compound

Product 1

HCID 57988791HCID 57988791, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

1-[5-Oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazole-4-carboxylic acid {6-amino-1-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl}-amide (100 mg, 0.14 mmol) was taken in dry DMF (3 ml) under argon atmosphere, added P2O5 (61.4 mg, 0.43 mmol) and dipped the reaction flask in a oil bath at 100° C. and stirred the reaction mixture for 5 min. Then the reaction mixture was cooled to room temperature and diluted with water and filtered the solid (56 mg, 57%) as pure product.

Workup

  1. customat 100° C.
  2. filtrationfiltered the solid (56 mg, 57%) as pure product

Sources & evidence

ORD record
ord-106a3c62fe144550a0ffc52883d6b709
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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