Ethanamine, 2,2,2-trifluoro- → HCID 178465610, compound

HRID 889157Notes

Reaction equation

HRID 889157 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].[ClH:7].[C:8](=[NH:13])(OCC)[CH3:9]>C(O)C>[ClH:7].[F:1][C:2]([F:6])([F:5])[CH2:3][NH:4][C:8](=[NH:13])[CH3:9]

Participants

4

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)

Product 1

HCID 178465610HCID 178465610, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2,2,2-trifluoroethylamine (3 ml), ethyl acetimidate hydrochloride (4.8 g) and ethanol (12 ml) was stirred at room temperature for 90 minutes, and then stirred overnight at 80° C. The reaction mixture was concentrated under reduced pressure to obtain the title compound (6.66 g).

Workup

  1. stirringstirred overnight at 80° C
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-80ce16101ea54500bf8d07ee72773d25
Source dataset
uspto-grants-2012_08
Patent number
US08252810B2

Reaction notes

Loading…