Hydrochloric Acid → HCID 66760013, compound

HRID 889212Notes

Reaction equation

HRID 889212 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:18])[NH:16][CH3:17])=[CH:11][N:10]=1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:17][NH:16][C:15]([C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][C:6]([OH:19])=[O:5])=[N:10][CH:11]=1)=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66760821HCID 66760821, compound

Product 1

HCID 66760013HCID 66760013, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl-3(5-methylcarbamoyl-pyridin-2-yl)propionate (0.29 g, 1.10 mmol) was dissolved in 10 mL of a 4 N hydrogen chloride solution in dioxane and stirred overnight. Evaporation of the solvent gave 0.27 mg of 3(5-methylcarbamoyl-pyridin-2-yl)propionic acid hydrochloride. LCMS 209 (M+1)

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-00cf7c1d4d2445abb97b87b8a20d6783
Source dataset
uspto-grants-2012_08
Patent number
US08252793B2

Reaction notes

Loading…