反应详情

A mixture of 1-benzyloxy-3-fluoro-2-nitrobenzene (1.32 g, 5.34 mmol), SnCl2 (4.96 g, 26.2 mmol), and 1N HCl (5.5 mL, 5.5 mmol) in EtOH (25 mL) is refluxed for 18 h. The mixture is concentrated and stirred with EtOAc and 1N NaOH solution. Solid NaOH is added until strongly basic. The precipitate is removed by filtration, and the organic phase is separated. It is then dried and concentrated. The residue is purified to give the title compound: MS (M+H)+=218.

1. temperatureis refluxed for 18 h
2. concentrationThe mixture is concentrated
3. additionSolid NaOH is added until strongly basic
4. customThe precipitate is removed by filtration
5. customthe organic phase is separated
6. customIt is then dried
7. concentrationconcentrated
8. customThe residue is purified