5-(2-Benzyloxy-6-fluoro-4-iodophenyl)-2-benzyloxymethyl-1,1-dioxo-1,2,5-thiadiazolidin-3-one → {2-[3-Benzyloxy-4-(5-benzyloxymethyl-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-5-fluorobenzyl]-5-methylphenyl}-carbamic acid tert-butyl ester

HRID 889251Notes

Reaction equation

HRID 889251 reaction equation
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=1[CH2:15]I)([CH3:4])([CH3:3])[CH3:2].[CH2:18]([O:25][C:26]1[CH:31]=[C:30](I)[CH:29]=[C:28]([F:33])[C:27]=1[N:34]1[S:38](=[O:40])(=[O:39])[N:37]([CH2:41][O:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[C:36](=[O:50])[CH2:35]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=1[CH2:15][C:30]1[CH:29]=[C:28]([F:33])[C:27]([N:34]2[CH2:35][C:36](=[O:50])[N:37]([CH2:41][O:42][CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[S:38]2(=[O:40])=[O:39])=[C:26]([O:25][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:31]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 684293105-(2-Benzyloxy-6-fluoro-4-iodophenyl)-2-benzyloxymethyl-1,1-dioxo-1,2,5-thiadiazolidin-3-oneHCID 68429608(2-Iodomethyl-5-methylphenyl)-carbamic acid tert-butyl ester

Product 1

HCID 68429549{2-[3-Benzyloxy-4-(5-benzyloxymethyl-1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-5-fluorobenzyl]-5-methylphenyl}-carbamic acid tert-butyl ester

Procedure

The title compound is prepared analogously to Example 1, Step M, with (2-iodomethyl-5-methylphenyl)-carbamic acid tert-butyl ester and 5-(2-benzyloxy-6-fluoro-4-iodophenyl)-2-benzyloxymethyl-1,1-dioxo-1,2,5-thiadiazolidin-3-one.

Sources & evidence

ORD record
ord-9f4c1800279041d79fb03d26307d09e7
Source dataset
uspto-grants-2012_08
Patent number
US08252820B2

Reaction notes

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