2-Benzyloxy-4,6-difluoronitrobenzene → 2-(Benzyloxy)-4,6-difluoroaniline

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Reaction Steps

2-Benzyloxy-4,6-difluoronitrobenzene (1.0 g, 3.77 mmol) is reduced in EtOAc (18 mL) and 100 mg of 5% platinum on carbon under a hydrogen balloon for 6 h. The mixture is filtered through Celite and solvent removed under reduced pressure. The residue is purified by column chromatography to give a yellow liquid as the title compound.

Provenance & Evidence