Hydrochloric Acid → 2,2-Dimethylhept-6-enoic acid

HRID 889278Notes

Reaction equation

HRID 889278 reaction equation
C([O:3][C:4](=[O:13])[C:5]([CH3:12])([CH3:11])[CH2:6][CH2:7][CH2:8][CH:9]=[CH2:10])C.[OH-].[Na+].Cl>CO>[CH3:11][C:5]([CH3:12])([CH2:6][CH2:7][CH2:8][CH:9]=[CH2:10])[C:4]([OH:13])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15680402HCID 15680402, compound

Product 1

HCID 156804032,2-Dimethylhept-6-enoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,2-dimethyl-hept-6-enoic acid ethyl ester (600 mg, 3.3 mmol) in MeOH (10 mL) is added 6N NaOH (5 mL) and the suspension is stirred at RT for 18 h. The solution is acidified with 1N HCl and extracted with EtOAc. The organic layer is dried, filtered and the solvent is removed under reduced pressure to afford the product which is used directly in the next step.

Workup

  1. extractionextracted with EtOAc
  2. customThe organic layer is dried
  3. filtrationfiltered
  4. customthe solvent is removed under reduced pressure
  5. customto afford the product which

Sources & evidence

ORD record
ord-bf0fbb7b843348ac8b3e38ef560c9b9a
Source dataset
uspto-grants-2012_08
Patent number
US08252820B2

Reaction notes

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