Hydrazine hydrate (1:1) → 2-Hydrazinyl-4-methylpyridine

Temperature

150 °C

3.33 g (30.0 mmol) 2-fluoro-4-methylpyridine are initially introduced into 40 ml 2-ethoxyethanol, 14.6 ml (15.0 g, 300 mmol) hydrazine hydrate are added to the solution and the mixture is stirred at the boil (150° C. bath temperature) for 16 h. The reaction solution is concentrated on a rotary evaporator, the residue is introduced on to 100 ml water and the mixture is extracted with ethyl acetate (three times with 100 ml each time). The combined organic phases are dried over sodium sulfate, filtered and concentrated. The residue obtained is dried in vacuo.

1. additionare added to the solution
2. concentrationThe reaction solution is concentrated on a rotary evaporator
3. additionthe residue is introduced on to 100 ml water
4. extractionthe mixture is extracted with ethyl acetate (three times with 100 ml each time)
5. dry with materialThe combined organic phases are dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue obtained
9. customis dried in vacuo

ORD record

ord-95961ef2b4da4f77bc5a8ec7d2e25052

Source dataset

uspto-grants-2012_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08252817B2