反应详情

20.0 g (139 mmol) (6-chloropyridin-3-yl)methanol are heated under reflux overnight in 400 ml of a 35% strength aqueous hydrazine hydrate solution. The mixture is concentrated, toluene is added, the mixture is concentrated again and the residue is stirred with a mixture of methylene chloride, methanol and diethyl ether. The crystalline residue (hydrazine hydrochloride) is filtered off, the filtrate is concentrated and the residue is dried in vacuo.

1. concentrationThe mixture is concentrated
2. additiontoluene is added
3. concentrationthe mixture is concentrated again
4. filtrationThe crystalline residue (hydrazine hydrochloride) is filtered off
5. concentrationthe filtrate is concentrated
6. customthe residue is dried in vacuo