2-Hydrazinyl-5-(trifluoromethyl)pyridine → 4-Pyridin-3-yl-2-[5-(trifluoromethyl)pyridin-2-yl]-1,2-dihydro-3h-pyrazol-3-one

HRID 889304Notes

Reaction equation

HRID 889304 reaction equation
C(O[C:4](=[O:14])[C:5]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)=[CH:6]O)C.[NH:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][N:18]=1)[NH2:16]>>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:5]2[C:4](=[O:14])[N:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][N:18]=3)[NH:16][CH:6]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 14776422-Hydrazinyl-5-(trifluoromethyl)pyridineHCID 687080883-Hydroxy-2-pyridin-3-yl-acrylic acid ethyl ester

Product 1

HCID 591869284-Pyridin-3-yl-2-[5-(trifluoromethyl)pyridin-2-yl]-1,2-dihydro-3h-pyrazol-3-one

Procedure

The compound is prepared analogously to Example 2 from 580 mg (3.00 mmol) of the compound from Example 2A and 558 mg (3.00 mmol) 2-hydrazino-5-(trifluoromethyl)pyridine.

Sources & evidence

ORD record
ord-43d41458e9f249489f0304243a409c5c
Source dataset
uspto-grants-2012_08
Patent number
US08252817B2

Reaction notes

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