2-methoxy-N-(4-methoxybenzyl)ethanamine → HCID 86641385, compound

HRID 889464Notes

Reaction equation

HRID 889464 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1.[Cl:15][C:16]1[CH:17]=[C:18](N(C2CC2)CC2C=CC(OC)=CC=2)[C:19]2[N:20]([C:22]([C:25]#[N:26])=[CH:23][N:24]=2)[N:21]=1>>[Cl:15][C:16]1[CH:17]=[C:18]([N:5]([CH2:6][C:7]2[CH:8]=[CH:9][C:10]([O:13][CH3:14])=[CH:11][CH:12]=2)[CH2:4][CH2:3][O:2][CH3:1])[C:19]2[N:20]([C:22]([C:25]#[N:26])=[CH:23][N:24]=2)[N:21]=1

Participants

3

Reactant 2

HCID 32858732-methoxy-N-(4-methoxybenzyl)ethanamineHCID 593137576-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

Product 1

HCID 86641385HCID 86641385, compound

Procedure

15A was prepared from 2-methoxy-N-(4-methoxybenzyl)ethanamine and 1F following the procedure employed in the preparation of 1G. HPLC: Rt=3.20 min. (CHROMOLITH® column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 min. containing 0.1% TFA, 4 mL/min., monitoring at 220 nm). MS (ES): m/z=372.1 [M+H]+.

Workup

  1. washHPLC: Rt=3.20 min. (CHROMOLITH® column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 min. containing 0.1% TFA, 4 mL/min., monitoring at 220 nm)

Sources & evidence

ORD record
ord-7f364d7fe54e45f596a7dc7725d5d54c
Source dataset
uspto-grants-2012_08
Patent number
US08252795B2

Reaction notes

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