反应详情

温度

100 °C

Ethyl {4-[4,9-bis(ethyloxy)-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-3-fluorophenyl}acetate (0.050 g, 0.11 mmol) was dissolved in glacial acetic acid (2 ml) and 2N hydrochloric acid (2 ml) added which caused precipitation. The reaction mixture was heated to 100° C. under argon (the precipitate went back into solution) for 2 hours. The reaction mixture was cooled to room temperature and water added with stirring for 5 minutes. A solid precipitate formed which was filtered, washed with water, and collected to give the title compound as a yellow solid. The product was dried overnight in a vacuum oven (0.024 g, 0.05 mmol).

1. customprecipitation
2. customfor 2 hours
3. temperatureThe reaction mixture was cooled to room temperature
4. additionwater added
5. customA solid precipitate formed which
6. filtrationwas filtered
7. washwashed with water
8. customcollected