Formaldehyde → HCID 86641031, compound

HRID 889527Notes

Reaction equation

HRID 889527 reaction equation
[CH2:1]=O.[CH:3](=[O:7])[CH:4]([CH3:6])[CH3:5].[CH2:8]([CH2:15][NH2:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH3:5][C:4]([CH3:1])([CH2:6][NH:16][CH2:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:3]=[O:7]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 1001PhenethylamineHCID 6561Isobutyraldehyde

Product 1

HCID 86641031HCID 86641031, compound

Procedure

Under the same conditions as for the preparation of 2,2-dimethyl-3-(N-morpholino)propanal, 39.2 g (0.47 mol) of 36% aqueous formaldehyde were reacted with 35.6 g (0.49 mol) of isobutyraldehyde and 57.0 g (0.47 mol) of N-benzylmethylamine, and worked up. The product distilled at a top temperature of 74° C. and a pressure of 4·10−2 mbar. Yield: 80.6 g (83% of theory) as a colorless, clear and almost odorless liquid which had an amine content of 4.83 mmol N/g.

Workup

  1. distillationThe product distilled at a top temperature of 74° C.

Sources & evidence

ORD record
ord-99a62555f04a4e7590bc4ad299b9ea44
Source dataset
uspto-grants-2012_08
Patent number
US08252859B2

Reaction notes

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