Formaldehyde → HCID 86641032, compound

HRID 889529Notes

Reaction equation

HRID 889529 reaction equation
[CH2:1]=O.[CH:3](=[O:7])[CH:4]([CH3:6])[CH3:5].[CH:8]1([CH2:14][NH2:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH3:5][C:4]([CH3:1])([CH2:6][NH:15][CH2:14][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH:3]=[O:7]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 6561IsobutyraldehydeHCID 76688Cyclohexanemethylamine

Product 1

HCID 86641032HCID 86641032, compound

Procedure

Under the same conditions as for the preparation of 2,2-dimethyl-3-(N-morpholino)propanal, 36.8 g (0.44 mol) of 36% aqueous formaldehyde were reacted with 33.4 g (0.46 mol) of isobutyraldehyde and 50.0 g (0.44 mol) of N-cyclohexylmethylamine, and worked up. The product distilled at a top temperature of 69° C. and a pressure of 4·10−2 mbar. Yield: 65.8 g (76% of theory) as a colorless, clear liquid smelling of amine, which had an amine content of 4.94 mmol N/g.

Workup

  1. distillationThe product distilled at a top temperature of 69° C.

Sources & evidence

ORD record
ord-bf303f87e9074f6694e79fc5a07f2189
Source dataset
uspto-grants-2012_08
Patent number
US08252859B2

Reaction notes

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