Benzylamine → 3-(Benzylamino)propanol

HRID 889834노트

반응식

HRID 889834 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[CH2:6](N)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O1CCCC1.C(OCC)(=O)C>[CH2:6]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 7504BenzylamineHCID 90863-Amino-1-propanol

생성물 1

HCID 784483-(Benzylamino)propanol수율 61%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

3-amino-1-propanol (150 g) was dissolved in tetrahydrofuran (200 mL), followed by the addition of benzylamine(23.8 g). The mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was diluted with ethyl acetate, was sequentially washed with water and a saturated aqueous solution of sodium chloride, and was then dried over anhydrous sodium sulfate. The solvent was removed to obtain 3-(benzylamino)-1-propanol (20.1 g, 61%).

후처리

  1. washwas sequentially washed with water
  2. dry with materiala saturated aqueous solution of sodium chloride, and was then dried over anhydrous sodium sulfate
  3. customThe solvent was removed

출처 및 근거

ORD 기록
ord-4a233f97f6f048c6966ab754563802cb
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06995153B2

반응 노트

불러오는 중…