Benzylamine → 3-(Benzylamino)propanol

HRID 889834Notes

Reaction equation

HRID 889834 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[CH2:6](N)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O1CCCC1.C(OCC)(=O)C>[CH2:6]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 7504BenzylamineHCID 90863-Amino-1-propanol

Product 1

HCID 784483-(Benzylamino)propanolYield 61%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-amino-1-propanol (150 g) was dissolved in tetrahydrofuran (200 mL), followed by the addition of benzylamine(23.8 g). The mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was diluted with ethyl acetate, was sequentially washed with water and a saturated aqueous solution of sodium chloride, and was then dried over anhydrous sodium sulfate. The solvent was removed to obtain 3-(benzylamino)-1-propanol (20.1 g, 61%).

Workup

  1. washwas sequentially washed with water
  2. dry with materiala saturated aqueous solution of sodium chloride, and was then dried over anhydrous sodium sulfate
  3. customThe solvent was removed

Sources & evidence

ORD record
ord-4a233f97f6f048c6966ab754563802cb
Source dataset
uspto-grants-2006_02
Patent number
US06995153B2

Reaction notes

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